Welcome to the MacCoss Lab!
We are a protein mass spectrometry lab located in the Department of Genome Sciences at the University of Washington in Seattle.
The focus of our research is in the development of stable isotope and mass
spectrometry based approaches to improve our understanding of biology on a
molecular, cellular, and whole organism level. Presently, individuals in the
laboratory are working on technology for
- Automating biochemical sample preparation methods for the analysis of protein mixtures
- Developing in vivo stable isotope methods for studying protein metabolism
- Increasing the dynamic range of liquid chromatography-mass spectrometry for the analysis of peptides
- Developing computational tools for the automated conversion of mass spectrometry data into biologically meaningful results
Useful Info for Mass Spectrometry Based Proteomics
- A simple way to plumb a traditional binary HPLC system for nanoflow chromatography. Download PDF
- Simple and robust nanospray stages for Thermo Fisher Ion Max Source. Go to UW Proteomics Resource website
- Simple amino acid calculator.
Photos of the Lab and Lab Outings
We work hard and play hard. Many of these events have been captured on film. More ...
Recent News & Updates
Sept 24, 2009Skyline v0.5 Released
The latest release of our popular software tool for building Selected Reaction Monitoring (SRM) / Multiple Reaction Monitoring (MRM) methods and analyzing the resulting mass spectrometer data. More ...
May 2009Interview by Environmental Health Perspective
Discussion on the use of targeted proteomics for the analysis of environmental toxicants on proteins. More ...
Feb 26, 2009MacCoss honored at UW Early Career Award Recognition
Four Assistant Professors recognized for winning national awards. More ...
Dec 19, 2008Mike MacCoss wins 2007 PECASE Award
The Presidential Early Career Award for Scientists and Engineers is the nation's highest honor for scientists at the onset of their careers.
NIH Press ReleaseUW Press Release