developed to provide a simple way to view the expected isotope
distribution for biological molecules measured by mass
spectrometry. The program also includes the the ability to
consider enriched stable isotopes.
Input is either as a
peptide sequence or an elemental composition through the graphical user
The algorithm for
predicting the isotope distribution is based on the approach reported
by Kubinyi, Analytica Chimica Acta
247 (1991) 107-119. The C, H, O, and N isotope abundances are
specific to biological molecules (Dwight E. Matthews personal
communication). All other elemental isotope abundances were
obtained from Biemann, Mass
Spectrometry, Organic Chemical Applications, McGraw-Hill New York,
IDCalc is free
for non-profit use. Source code is available upon request.
IDCalc is academic software and is use at your own risk.
IDCalc has been
tested using Microsoft Windows XP and Vista.
You might need to install the latest version of the Visual Basic 6 Run Time first before the executable will run on your computer. Go here
to download the latest VB6 Run Time libraries from Microsoft. Also, on Windows 7 I have found that you have to register the COMDLG32.OCX library. You can do this by running "regsvr32 C:\SWTOOLS\Apps\MMCfto\System32\Redist\MS\System\COMDLG32.OCX"
mouse click here and select "Save link as ..."
IDCalc is Copyright © 2008 University of Washington. All rights
reserved. Written by Michael J. MacCoss, in the Department of Genome
Sciences at the University
Department of Genome Sciences
University of Washington